|Application ||WB, E|
|Other Accession||NP_001092281.1, NP_001092282.1|
|Calculated MW||55756 Da|
|Antigen Region||407-436 aa|
|Other Names||Septin-8, SEPT8, KIAA0202|
|Target/Specificity||This SEPT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-436 amino acids from the C-terminal region of human SEPT8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEPT8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Note=In platelets, found in areas surrounding alpha-granules.|
|Tissue Location||Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
SEPT8 is a member of the highly conserved septin family. Septins are 40- to 60-kD GTPases that assemble as filamentous scaffolds. They are involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking (Blaser et al., 2003 [PubMed 12909369]).
Souza, T.A., et al. Protein J. 29(5):328-335(2010)
Ridruechai, C., et al. Genes Immun. 11(5):416-422(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Xin, X., et al. J. Histochem. Cytochem. 55(11):1089-1094(2007)
Steels, J.D., et al. Cell Motil. Cytoskeleton 64(10):794-807(2007)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.