|Application ||WB, E|
|Other Accession||NP_001092281.1, NP_001092282.1|
|Calculated MW||55756 Da|
|Antigen Region||407-436 aa|
|Other Names||Septin-8, SEPT8, KIAA0202|
|Target/Specificity||This SEPT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-436 amino acids from the C-terminal region of human SEPT8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEPT8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Note=In platelets, found in areas surrounding alpha-granules.|
|Tissue Location||Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary|
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Provided below are standard protocols that you may find useful for product applications.
SEPT8 is a member of the highly conserved septin family. Septins are 40- to 60-kD GTPases that assemble as filamentous scaffolds. They are involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking (Blaser et al., 2003 [PubMed 12909369]).
Souza, T.A., et al. Protein J. 29(5):328-335(2010)
Ridruechai, C., et al. Genes Immun. 11(5):416-422(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Xin, X., et al. J. Histochem. Cytochem. 55(11):1089-1094(2007)
Steels, J.D., et al. Cell Motil. Cytoskeleton 64(10):794-807(2007)
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