|Application ||WB, E|
|Other Accession||B3GNI6, Q8C1B7, Q4R555, A2VE99, NP_060713.1|
|Predicted||Bovine, Monkey, Mouse, Rat|
|Calculated MW||49398 Da|
|Antigen Region||353-382 aa|
|Other Names||Septin-11, SEPT11|
|Target/Specificity||This SEPT11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-382 amino acids from the Central region of human SEPT11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEPT11 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell junction, synapse. Cell projection, dendritic spine. Cell projection, axon. Note=Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria|
|Tissue Location||Widely expressed, except in leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15485874]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Huang, G.L., et al. World J. Gastroenterol. 16(16):2046-2054(2010)
Mostowy, S., et al. J. Biol. Chem. 284(17):11613-11621(2009)
Ding, X., et al. Mol. Cells 25(3):385-389(2008)
Xin, X., et al. J. Histochem. Cytochem. 55(11):1089-1094(2007)
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