|Application ||WB, E|
|Other Accession||NP_056107.1, NP_001171725.1|
|Calculated MW||122856 Da|
|Antigen Region||1002-1031 aa|
|Other Names||Extended synaptotagmin-1, E-Syt1, Membrane-bound C2 domain-containing protein, ESYT1, FAM62A, KIAA0747, MBC2|
|Target/Specificity||This ESYT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1002-1031 amino acids from the C-terminal region of human ESYT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ESYT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FAM62A, KIAA0747, MBC2|
|Function||Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Peripheral membrane protein Note=Localizes primarily to the endoplasmic reticulum. Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
ESYT1 may play a role as calcium-regulated intrinsic membrane protein (By similarity).
Craxton, M. BMC Genomics 8, 259 (2007) :
Laveder, P., et al. Nucleic Acids Res. 30 (9), E38 (2002) :
Morris, N.J., et al. Biochim. Biophys. Acta 1431(2):525-530(1999)
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