|Application ||WB, E|
|Calculated MW||80643 Da|
|Antigen Region||472-501 aa|
|Other Names||Pre-B-cell leukemia transcription factor-interacting protein 1, Hematopoietic PBX-interacting protein, PBXIP1, HPIP|
|Target/Specificity||This PBXIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 472-501 amino acids from the C-terminal region of human PBXIP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PBXIP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.|
|Cellular Location||Cytoplasm, cytoskeleton Nucleus. Note=Shuttles between the nucleus and the cytosol (PubMed:12360403). Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160)|
|Tissue Location||Expressed in early hematopoietic precursors.|
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Provided below are standard protocols that you may find useful for product applications.
Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Lim, J., et al. Cell 125(4):801-814(2006)
Abramovich, C., et al. Oncogene 21(44):6766-6771(2002)
Abramovich, C., et al. J. Biol. Chem. 275(34):26172-26177(2000)
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