PBXIP1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q96AQ6 |
Other Accession | NP_065385.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 80643 Da |
Antigen Region | 472-501 aa |
Gene ID | 57326 |
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Other Names | Pre-B-cell leukemia transcription factor-interacting protein 1, Hematopoietic PBX-interacting protein, PBXIP1, HPIP |
Target/Specificity | This PBXIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 472-501 amino acids from the C-terminal region of human PBXIP1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PBXIP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PBXIP1 |
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Synonyms | HPIP |
Function | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor- alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. |
Cellular Location | Cytoplasm, cytoskeleton. Nucleus Note=Shuttles between the nucleus and the cytosol (PubMed:12360403) Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160) |
Tissue Location | Expressed in early hematopoietic precursors. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.
References
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Lim, J., et al. Cell 125(4):801-814(2006)
Abramovich, C., et al. Oncogene 21(44):6766-6771(2002)
Abramovich, C., et al. J. Biol. Chem. 275(34):26172-26177(2000)
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