|Application ||WB, E|
|Calculated MW||50864 Da|
|Antigen Region||73-102 aa|
|Other Names||Beta-1, 3-galactosyl-O-glycosyl-glycoprotein beta-1, 6-N-acetylglucosaminyltransferase 3, C2GnT-mucin type, C2GnT-M, hC2GnT-M, Core 2/core 4 beta-1, 6-N-acetylglucosaminyltransferase, C2/4GnT, GCNT3|
|Target/Specificity||This GCNT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-102 amino acids from the N-terminal region of human GCNT3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GCNT3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.
Tan, S., et al. Am. J. Respir. Cell Mol. Biol. 36(6):737-745(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Huang, M.C., et al. Oncogene 25(23):3267-3276(2006)
Beum, P.V., et al. Am. J. Respir. Cell Mol. Biol. 29(1):48-56(2003)
Schwientek, T., et al. J. Biol. Chem. 274(8):4504-4512(1999)
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