|Application ||WB, E|
|Calculated MW||28531 Da|
|Antigen Region||8-37 aa|
|Other Names||N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, Phosphatidylinositol-glycan biosynthesis class L protein, PIG-L, PIGL|
|Target/Specificity||This PIGL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human PIGL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PIGL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an enzyme that catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI). Study of a similar rat enzyme suggests that this protein localizes to the endoplasmic reticulum. [provided by RefSeq].
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Pottekat, A., et al. J. Biol. Chem. 279(16):15743-15751(2004)
Kinoshita, T., et al. Curr Opin Chem Biol 4(6):632-638(2000)
Watanabe, R., et al. Biochem. J. 339 (PT 1), 185-192 (1999) :
Nakamura, N., et al. J. Biol. Chem. 272(25):15834-15840(1997)
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