- CITATIONS: 1
|Application ||WB, E|
|Other Accession||Q8IZJ0, NP_742151.2|
|Calculated MW||21706 Da|
|Antigen Region||34-63 aa|
|Other Names||Interferon lambda-3, IFN-lambda-3, Cytokine Zcyto22, Interleukin-28B, IL-28B, Interleukin-28C, IL-28C, IFNL3, IL28B, IL28C, ZCYTO22|
|Target/Specificity||This IL28B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-63 amino acids from the N-terminal region of human IL28B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL28B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||IL28B, IL28C, ZCYTO22|
|Function||Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.|
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
Lindh, M., et al. Hepatology 52(5):1860-1861(2010)
Pineda, J.A., et al. Clin. Infect. Dis. 51(7):788-795(2010)
Grebely, J., et al. Hepatology 52(4):1216-1224(2010)
Stattermayer, A.F., et al. Clin. Gastroenterol. Hepatol. (2010) In press :
Iwata, R., et al. J. Viral Hepat. (2010) In press :
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