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CCL7 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CCL7 Antibody (Center) AP16860c
    CCL7 Antibody (Center) (Cat. #AP16860c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CCL7 antibody detected the CCL7 protein (arrow).
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  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P80098
Other Accession NP_006264.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 11200 Da
Antigen Region 25-54 aa
Additional Information
Gene ID 6354
Other Names C-C motif chemokine 7, Monocyte chemoattractant protein 3, Monocyte chemotactic protein 3, MCP-3, NC28, Small-inducible cytokine A7, CCL7, MCP3, SCYA6, SCYA7
Target/Specificity This CCL7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the Central region of human CCL7.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCL7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCL7
Synonyms MCP3, SCYA6, SCYA7
Function Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.
Cellular Location Secreted.
Research Areas
Citations (0)
citation

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Background

This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q.

References

McGovern, D.P., et al. Hum. Mol. Genet. 19(17):3468-3476(2010)
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :

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$ 182.50
$ 70.00
Cat# AP16860c
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