|Application ||WB, E|
|Calculated MW||11200 Da|
|Antigen Region||25-54 aa|
|Other Names||C-C motif chemokine 7, Monocyte chemoattractant protein 3, Monocyte chemotactic protein 3, MCP-3, NC28, Small-inducible cytokine A7, CCL7, MCP3, SCYA6, SCYA7|
|Target/Specificity||This CCL7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the Central region of human CCL7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCL7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MCP3, SCYA6, SCYA7|
|Function||Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q.
McGovern, D.P., et al. Hum. Mol. Genet. 19(17):3468-3476(2010)
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
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