|Application ||WB, E|
|Other Accession||Q9TUN9, Q61056, O18784, NP_003295.1|
|Predicted||Bovine, Mouse, Rabbit|
|Calculated MW||91212 Da|
|Antigen Region||765-793 aa|
|Other Names||Short transient receptor potential channel 1, TrpC1, Transient receptor protein 1, TRP-1, TRPC1, TRP1|
|Target/Specificity||This TRPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 765-793 amino acids from the C-terminal region of human TRPC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRPC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Seems to be ubiquitous.|
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Provided below are standard protocols that you may find useful for product applications.
TRPC1 belongs to the transient receptor potential (TRP) superfamily of cation channels. TRP cation channels are involved in diverse physiologic processes, including receptor- and store-operated Ca(2+) entry, mineral absorption, and cell death. They also function as sensors for pain, heat, cold, sound, stretch, and osmotic changes (Zhang et al., 2009 [PubMed 19193631]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Bomben, V.C., et al. Glia 58(10):1145-1156(2010)
Lu, M., et al. J. Mol. Endocrinol. 44(5):285-294(2010)
Gonzalez-Cobos, J.C., et al. Front. Biosci. 15, 1023-1039 (2010) :
Ingueneau, C., et al. J. Cell. Mol. Med. 13 (8B), 1620-1631 (2009) :
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