|Application ||WB, E|
|Calculated MW||99562 Da|
|Antigen Region||834-862 aa|
|Other Names||Short transient receptor potential channel 7, TrpC7, Transient receptor protein 7, TRP-7, hTRP7, TRPC7, TRP7|
|Target/Specificity||This TRPC7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 834-862 amino acids from the C-terminal region of human TRPC7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRPC7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Nucleus envelope|
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Provided below are standard protocols that you may find useful for product applications.
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Miyagi, K., et al. J. Biol. Chem. 284(49):34400-34412(2009)
Graubert, T.A., et al. PLoS ONE 4 (2), E4583 (2009) :
Abed, E., et al. Cell Prolif. 40(6):849-865(2007)
Numaga, T., et al. Handb Exp Pharmacol 179, 143-151 (2007) :
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