|Application ||WB, E|
|Calculated MW||21642 Da|
|Antigen Region||98-127 aa|
|Other Names||Syndecan-4, SYND4, Amphiglycan, Ryudocan core protein, SDC4|
|Target/Specificity||This SDC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-127 amino acids from the Central region of human SDC4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SDC4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).|
|Cellular Location||Isoform 1: Membrane; Single- pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.|
|Tissue Location||Expressed in epithelial and fibroblastic cells.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22.
Buhligen, J., et al. J. Cell. Physiol. 225(3):905-914(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Carvallo, L., et al. J. Biol. Chem. 285(38):29546-29555(2010)
Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)
Hallberg, G., et al. Reprod. Biol. Endocrinol. 8, 35 (2010) :
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