|Application ||WB, E|
|Other Accession||Q99L90, NP_006328.2, NP_001012300.1|
|Calculated MW||51803 Da|
|Antigen Region||35-63 aa|
|Other Names||Microspherule protein 1, 58 kDa microspherule protein, Cell cycle-regulated factor p78, INO80 complex subunit J, MCRS2, MCRS1, INO80Q, MSP58|
|Target/Specificity||This MCRS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-63 amino acids from the N-terminal region of human MCRS1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MCRS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602).|
|Cellular Location||Nucleus. Nucleus, nucleolus Cytoplasm. Note=In microspherules in the nucleolus.|
|Tissue Location||Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
MCRS1 modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. May be an inhibitor of TERT telomerase activity.
Lin, W., et al. J. Cell. Mol. Med. 13 (11-12), 4608-4622 (2009) :
Shi, H., et al. Cancer Sci. 100(9):1585-1590(2009)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Wu, J.L., et al. BMC Cell Biol. 10, 9 (2009) :
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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