|Application ||WB, E|
|Other Accession||D3ZR10, Q5DU00, NP_001182539.1, NP_057440.2|
|Calculated MW||52834 Da|
|Antigen Region||306-334 aa|
|Other Names||Doublecortin domain-containing protein 2, Protein RU2S, DCDC2, KIAA1154, RU2|
|Target/Specificity||This DCDC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-334 amino acids from the Central region of human DCDC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DCDC2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in neuronal migration during development of the cerebral neocortex.|
|Tissue Location||Ubiquitously expressed. In brain, highly expressed in the entorhinal cortex, inferior temporal cortex, medial temporal cortex, hypothalamus, amygdala and hippocampus|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein with two doublecortin peptide domains. This domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Mutations in this gene have been associated with Reading Disability (RD), also referred to as developmental dyslexia.
Couto, J.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2), 447-462 (2010) :
Meda, S.A., et al. Neuroimage (2009) In press :
Couto, J.M., et al. Biol. Psychiatry 66(4):368-375(2009)
Wilcke, A., et al. Ann Dyslexia 59(1):1-11(2009)
Meda, S.A., et al. Brain Imaging Behav 2(1):21-26(2008)
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