|Application ||WB, E|
|Calculated MW||113736 Da|
|Antigen Region||262-290 aa|
|Other Names||Hermansky-Pudlak syndrome 3 protein, HPS3|
|Target/Specificity||This HPS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-290 amino acids from the N-terminal region of human HPS3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HPS3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in early stages of melanosome biogenesis and maturation.|
|Tissue Location||Widely expressed. Higher levels of expression are observed in kidney, liver and placenta|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein containing a potential clathrin-binding motif, consensus dileucine signals, and tyrosine-based sorting signals for targeting to vesicles of lysosomal lineage. The encoded protein may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 3. Alternate splice variants exist, but their full length sequence has not been determined. [provided by RefSeq].
Torres-Serrant, M., et al. J. Pediatr. Hematol. Oncol. 32(6):448-453(2010)
Huizing, M., et al. Platelets 18(2):150-157(2007)
Santiago Borrero, P.J., et al. J. Invest. Dermatol. 126(1):85-90(2006)
Boissy, R.E., et al. Am. J. Pathol. 166(1):231-240(2005)
Helip-Wooley, A., et al. BMC Cell Biol. 6, 33 (2005) :
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