HPS3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q969F9 |
Other Accession | NP_115759.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 113736 Da |
Antigen Region | 262-290 aa |
Gene ID | 84343 |
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Other Names | Hermansky-Pudlak syndrome 3 protein, HPS3 |
Target/Specificity | This HPS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-290 amino acids from the N-terminal region of human HPS3. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | HPS3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HPS3 |
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Function | Involved in early stages of melanosome biogenesis and maturation. |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q91VB4}. Cytoplasm, cytosol |
Tissue Location | Widely expressed. Higher levels of expression are observed in kidney, liver and placenta |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein containing a potential clathrin-binding motif, consensus dileucine signals, and tyrosine-based sorting signals for targeting to vesicles of lysosomal lineage. The encoded protein may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 3. Alternate splice variants exist, but their full length sequence has not been determined. [provided by RefSeq].
References
Torres-Serrant, M., et al. J. Pediatr. Hematol. Oncol. 32(6):448-453(2010)
Huizing, M., et al. Platelets 18(2):150-157(2007)
Santiago Borrero, P.J., et al. J. Invest. Dermatol. 126(1):85-90(2006)
Boissy, R.E., et al. Am. J. Pathol. 166(1):231-240(2005)
Helip-Wooley, A., et al. BMC Cell Biol. 6, 33 (2005) :
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