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IQGAP1 Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP16889a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP16889a-ev20 | Ev20 size 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
IQGAP1 Antibody (N-term) - Product info | |
| Application | WB
|
| Primary Accession | P46940 |
| Other Accession | NP_003861.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 189252 Da |
IQGAP1 Antibody (N-term) - Additional info | |
| Gene ID 8826 | |
| Other Names IQGAP1; KIAA0051; Ras GTPase-activating-like protein IQGAP1; p195 | |
| Target/Specificity This IQGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-285 amino acids from the N-terminal region of human IQGAP1. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions IQGAP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
IQGAP1 Antibody (N-term) - Protein Information | |
| Name IQGAP1 | |
| Synonyms KIAA0051 | |
| Function Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth | |
| Cellular Location Cell membrane. | |
| Tissue Location Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas | |
IQGAP1 Antibody (N-term) - Related products
AP16889a: IQGAP1 Antibody (N-term)
IQGAP1 Antibody (N-term) - Application data
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IQGAP1 Antibody (N-term) (Cat. #AP16889a) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the IQGAP1 antibody detected the IQGAP1 protein (arrow).
IQGAP1 Antibody (N-term) - Research Areas
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BACKGROUND
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.
REFERENCES
Hayashi, H., et al. Int. J. Cancer 126(11):2563-2574(2010) Liang, S., et al. Proteomics 10(7):1474-1483(2010) Nakhaei-Nejad, M., et al. Eur. J. Immunol. 40(1):204-213(2010) Wang, J.B., et al. J. Cell. Sci. 122 (PT 12), 2024-2033 (2009) : Usatyuk, P.V., et al. J. Biol. Chem. 284(22):15339-15352(2009)
