|Application ||WB, E|
|Other Accession||NP_001001713.1, NP_031367.1|
|Calculated MW||26086 Da|
|Antigen Region||149-177 aa|
|Other Names||SH3 domain-binding glutamic acid-rich protein, SH3BGR protein, 21-glutamic acid-rich protein, 21-GARP, SH3BGR|
|Target/Specificity||This SH3BGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-177 amino acids from the Central region of human SH3BGR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SH3BGR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed in heart and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Proline-rich peptide sequences have been shown to play important roles in protein-protein interactions that occur in signal transduction pathways. SH3 domain binding glutamic acid-rich protein (SH3BGR), also designated 21-glutamic acid-rich protein (21-GARP), is a 239-amino acid protein differentially expressed in heart and skeletal muscle. Its proline-rich region contains the consensus sequence for an SH3-binding domain and its acidic C-terminal region contains a glutamic acid-rich domain which may assume a coiled-coil structure. SH3BGR may be part of a multimeric complex, as it contains 2 functional domains involved in protein-protein interactions.
Naukkarinen, J., et al. PLoS Genet. 6 (6), E1000976 (2010) :
Hu, Y.H., et al. BMC Genomics 7, 155 (2006) :
Sandri, C., et al. Hum. Genet. 114(5):517-519(2004)
Jiang, L.Q., et al. Hypertens. Res. 25(4):647-652(2002)
Scartezzini, P., et al. Hum. Genet. 99(3):387-392(1997)
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