NHLH1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q02575 |
Other Accession | NP_005589.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 14618 Da |
Antigen Region | 38-67 aa |
Gene ID | 4807 |
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Other Names | Helix-loop-helix protein 1, HEN-1, Class A basic helix-loop-helix protein 35, bHLHa35, Nescient helix loop helix 1, NSCL-1, NHLH1, BHLHA35, HEN1 |
Target/Specificity | This NHLH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-67 amino acids from the Central region of human NHLH1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NHLH1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NHLH1 |
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Synonyms | BHLHA35, HEN1 |
Function | May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM].
References
Manetopoulos, C., et al. Biochem. Biophys. Res. Commun. 307(4):891-899(2003)
Bao, J., et al. Development 127(2):425-435(2000)
Lipkowitz, S., et al. J. Biol. Chem. 267(29):21065-21071(1992)
Brown, L., et al. Proc. Natl. Acad. Sci. U.S.A. 89(18):8492-8496(1992)
Begley, C.G., et al. Proc. Natl. Acad. Sci. U.S.A. 89(1):38-42(1992)
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