|Application ||WB, E|
|Calculated MW||37216 Da|
|Antigen Region||225-254 aa|
|Other Names||Pregnancy-specific beta-1-glycoprotein 2, PS-beta-G-2, PSBG-2, Pregnancy-specific glycoprotein 2, Pregnancy-specific beta-1 glycoprotein E, PS-beta-E, PSG2, PSBG2|
|Target/Specificity||This PSG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-254 amino acids from the C-terminal region of human PSG2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PSG2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).
Tsavaris, N., et al. J Chemother 21(6):673-680(2009)
Mennuni, C., et al. Int. J. Cancer 117(3):444-455(2005)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
Grimwood, J., et al. Nature 428(6982):529-535(2004)
Teglund, S., et al. Genomics 23(3):669-684(1994)
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