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HKDC1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q2TB90 |
| Other Accession | NP_079406.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 102545 Da |
| Antigen Region | 825-853 aa |
| Gene ID | 80201 |
|---|---|
| Other Names | Putative hexokinase HKDC1, Hexokinase domain-containing protein 1, HKDC1 |
| Target/Specificity | This HKDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 825-853 amino acids from the C-terminal region of human HKDC1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HKDC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HKDC1 (HGNC:23302) |
|---|---|
| Function | Catalyzes the phosphorylation of hexose to hexose 6- phosphate, although at very low level compared to other hexokinases (PubMed:30517626). Has low glucose phosphorylating activity compared to other hexokinases (PubMed:30517626). Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (By similarity). |
| Cellular Location | Cytoplasm. Mitochondrion membrane; Peripheral membrane protein. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q91W97}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrion |
| Tissue Location | Widely expressed (PubMed:27459389, PubMed:29401404). Highly expressed in the brush border, surface epithelium and the myenteric plexus of the small and large intestines; the acinar centrocytes and interlobular ducts of the pancreas; and the alveolar macrophages in the lungs (at protein level) (PubMed:29401404) Present at moderate level in the thyroid follicular epithelium (at protein level) (PubMed:29401404). |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Neale, B.M., et al. J Am Acad Child Adolesc Psychiatry 49(9):906-920(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
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$ 182.50
$ 70.00
Cat# AP16912B
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