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POLS Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - POLS Antibody (Center) AP16915C
    POLS Antibody (Center) (Cat. #AP16915c) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the POLS antibody detected the POLS protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5XG87
Other Accession Q6PB75, NP_008930.1, NP_001165276.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 82360 Da
Antigen Region 152-180 aa
Additional Information
Gene ID 11044
Other Names Non-canonical poly(A) RNA polymerase PAPD7, DNA polymerase sigma, LAK-1, PAP-associated domain-containing protein 7, TRAMP-like complex polyadenylate polymerase, Terminal uridylyltransferase 5, TUTase 5, Topoisomerase-related function protein 4-1, TRF4-1, PAPD7, POLS, TRF4
Target/Specificity This POLS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-180 amino acids from the Central region of human POLS.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPOLS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAPD7
Synonyms POLS, TRF4
Function Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation.
Cellular Location Cytoplasm. Nucleus, nucleoplasm. Note=Excluded from nucleolus, weak staining detected in the cytoplasm
Citations (0)

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The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described.


Jarjanazi, H., et al. Hum. Mutat. 29(4):461-467(2008)
Carson, D.R., et al. Proc. Natl. Acad. Sci. U.S.A. 98(15):8270-8275(2001)
Wang, Z., et al. Science 289(5480):774-779(2000)
Walowsky, C., et al. J. Biol. Chem. 274(11):7302-7308(1999)

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$ 295.00
$ 99.00
Cat# AP16915C
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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