|Application ||WB, E|
|Other Accession||NP_803436.1, NP_001494.2|
|Calculated MW||92336 Da|
|Antigen Region||278-306 aa|
|Other Names||Phosphatidylinositol-glycan-specific phospholipase D, PI-G PLD, Glycoprotein phospholipase D, Glycosyl-phosphatidylinositol-specific phospholipase D, GPI-PLD, GPI-specific phospholipase D, GPLD1, PIGPLD1|
|Target/Specificity||This GPLD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 278-306 amino acids from the Central region of human GPLD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPLD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.|
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Provided below are standard protocols that you may find useful for product applications.
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.
Speliotes, E.K., et al. Hepatology 52(3):904-912(2010)
Tang, J.H., et al. Clin. Biochem. 42 (4-5), 400-407 (2009) :
Yuan, X., et al. Am. J. Hum. Genet. 83(4):520-528(2008)
Wright, M.H., et al. Biochem. Biophys. Res. Commun. 369(2):478-484(2008)
Shi, M., et al. Cancer Lett. 258(2):268-275(2007)
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