|Application ||WB, E|
|Calculated MW||50082 Da|
|Antigen Region||107-134 aa|
|Other Names||Sialic acid-binding Ig-like lectin 9, Siglec-9, CDw329, Protein FOAP-9, CD329, SIGLEC9|
|Target/Specificity||This SIGLEC9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-134 amino acids from the N-terminal region of human SIGLEC9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SIGLEC9 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine and spinal cordon|
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Provided below are standard protocols that you may find useful for product applications.
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Belisle, J.A., et al. Mol. Cancer 9, 118 (2010) :
von Gunten, S., et al. Shock 32(4):386-392(2009)
Rashmi, R., et al. Pediatr. Res. 66(3):266-271(2009)
Carlin, A.F., et al. Blood 113(14):3333-3336(2009)
Avril, T., et al. J. Immunol. 173(11):6841-6849(2004)
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