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PTP4A1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q93096 |
| Other Accession | Q78EG7, Q63739, Q9TSM6, NP_003454.1 |
| Reactivity | Human, Mouse |
| Predicted | Monkey, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 19815 Da |
| Antigen Region | 140-168 aa |
| Gene ID | 7803 |
|---|---|
| Other Names | Protein tyrosine phosphatase type IVA 1, PTP(CAAXI), Protein-tyrosine phosphatase 4a1, Protein-tyrosine phosphatase of regenerating liver 1, PRL-1, PTP4A1, PRL1, PTPCAAX1 |
| Target/Specificity | This PTP4A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-168 amino acids from the C-terminal region of human PTP4A1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PTP4A1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTP4A1 |
|---|---|
| Synonyms | PRL1, PTPCAAX1 |
| Function | Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. |
| Cellular Location | Cell membrane; Lipid-anchor. Early endosome. Endoplasmic reticulum. Cytoplasm Cytoplasm, cytoskeleton, spindle. Nucleus {ECO:0000250|UniProtKB:Q78EG7}. Note=And mitotic spindle |
| Tissue Location | Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells. [provided by RefSeq].
References
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Skinner, A.L., et al. Biochemistry 48(20):4262-4272(2009)
Luo, Y., et al. Biochemistry 48(8):1838-1846(2009)
Min, S.H., et al. Oncogene 28(4):545-554(2009)
Liu, Y.Q., et al. Arch. Pathol. Lab. Med. 132(8):1307-1312(2008)
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