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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PTPN18 Antibody (C-term)   

PTPN18 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PTPN18 Antibody (C-term) AP16925B
    PTPN18 Antibody (C-term) (Cat. #AP16925b) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the PTPN18 antibody detected the PTPN18 protein (arrow).
  • WB - PTPN18 Antibody (C-term) AP16925B
    Western blot analysis of PTPN18 (arrow) using rabbit polyclonal PTPN18 Antibody (C-term) (Cat. #AP16925b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PTPN18 gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99952
Other Accession Q61152, NP_055184.2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 50482 Da
Antigen Region 430-459 aa
Additional Information
Gene ID 26469
Other Names Tyrosine-protein phosphatase non-receptor type 18, Brain-derived phosphatase, PTPN18, BDP1
Target/Specificity This PTPN18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 430-459 amino acids from the C-terminal region of human PTPN18.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPTPN18 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTPN18
Synonyms BDP1
Function Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
Cellular Location Nucleus. Cytoplasm
Tissue Location Expressed in brain, colon and several tumor- derived cell lines.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].


Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Zhang, Y., et al. Mol. Cell Proteomics 4(9):1240-1250(2005)
Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)
Blanchetot, C., et al. Methods 35(1):44-53(2005)
Gandhi, T.K., et al. DNA Res. 12(2):79-89(2005)

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Cat# AP16925B
(40 western blots)
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