|Application ||WB, E|
|Other Accession||Q61152, NP_055184.2|
|Calculated MW||50482 Da|
|Antigen Region||430-459 aa|
|Other Names||Tyrosine-protein phosphatase non-receptor type 18, Brain-derived phosphatase, PTPN18, BDP1|
|Target/Specificity||This PTPN18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 430-459 amino acids from the C-terminal region of human PTPN18.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTPN18 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Expressed in brain, colon and several tumor- derived cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Zhang, Y., et al. Mol. Cell Proteomics 4(9):1240-1250(2005)
Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)
Blanchetot, C., et al. Methods 35(1):44-53(2005)
Gandhi, T.K., et al. DNA Res. 12(2):79-89(2005)
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