|Application ||WB, E|
|Other Accession||Q09325, P27115, P27808, NP_001108089.1, NP_001108090.1|
|Predicted||Mouse, Rabbit, Rat|
|Calculated MW||50878 Da|
|Antigen Region||159-187 aa|
|Other Names||Alpha-1, 3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, GNT-I, GlcNAc-T I, MGAT1, GGNT1, GLCT1, GLYT1, MGAT|
|Target/Specificity||This MGAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-187 amino acids from the Central region of human MGAT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MGAT1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GGNT1, GLCT1, GLYT1, MGAT|
|Function||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Appears to be present in all tissues.|
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Provided below are standard protocols that you may find useful for product applications.
There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene.
Henquet, M., et al. Transgenic Res. 19(4):535-547(2010)
Johansson, A., et al. Obesity (Silver Spring) 18(4):803-808(2010)
Bousman, C.A., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (8), 1025-1049 (2009) :
Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :
Saribas, A.S., et al. Biochem. Biophys. Res. Commun. 362(2):381-386(2007)
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