|Application ||WB, E|
|Other Accession||P55194, NP_061830.3|
|Calculated MW||75713 Da|
|Antigen Region||419-446 aa|
|Other Names||SH3 domain-binding protein 1, 3BP-1, SH3BP1|
|Target/Specificity||This SH3BP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 419-446 amino acids from the Central region of human SH3BP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SH3BP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
SH3BP1 binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho-or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity).
Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
Scott, M.P., et al. J. Biol. Chem. 277(31):28238-28246(2002)
Dunham, I., et al. Nature 402(6761):489-495(1999)
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