|Application ||WB, E|
|Other Accession||Q9Z0E0, Q2KJ97, NP_001014841.1, NP_055099.1|
|Calculated MW||78864 Da|
|Antigen Region||114-144 aa|
|Other Names||Neurochondrin, NCDN, KIAA0607|
|Target/Specificity||This NCDN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114-144 amino acids from the N-terminal region of human NCDN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NCDN Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin- concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.|
|Cellular Location||Cytoplasm, cytosol. Cell projection, dendrite. Note=Localizes to somatic regions of neurons|
|Tissue Location||Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord Weakly expressed in ovary, testis, fetal brain and small intestine.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described.
Dateki, M., et al. J. Biol. Chem. 280(21):20503-20508(2005)
Mochizuki, R., et al. Biochem. Biophys. Res. Commun. 310(4):1219-1226(2003)
Tchernev, V.T., et al. Mol. Med. 8(1):56-64(2002)
Ohoka, Y., et al. Biochem. Biophys. Res. Commun. 280(1):237-243(2001)
Mochizuki, R., et al. Biochim. Biophys. Acta 1490(3):367-368(2000)
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