|Application ||WB, E|
|Other Accession||Q64674, NP_003123.2|
|Calculated MW||33825 Da|
|Antigen Region||158-187 aa|
|Other Names||Spermidine synthase, SPDSY, Putrescine aminopropyltransferase, SRM, SPS1, SRML1|
|Target/Specificity||This SRM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 158-187 amino acids from the Central region of human SRM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SRM Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.|
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Provided below are standard protocols that you may find useful for product applications.
The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor.
Wu, H., et al. Biochemistry 46(28):8331-8339(2007)
Nishikawa, Y., et al. Biochem. J. 321 (PT 2), 537-543 (1997) :
Lakanen, J.R., et al. J. Med. Chem. 38(14):2714-2727(1995)
Kauppinen, L. FEBS Lett. 365(1):61-65(1995)
Kauppinen, L., et al. Biochem. J. 293 (PT 2), 513-516 (1993) :
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