|Application ||WB, E|
|Other Accession||NP_001137466.1, NP_003466.1, NP_001137465.1|
|Calculated MW||39945 Da|
|Antigen Region||326-354 aa|
|Other Names||Ras association domain-containing protein 7, HRAS1-related cluster protein 1, RASSF7, C11orf13, HRC1|
|Target/Specificity||This RASSF7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-354 amino acids from the C-terminal region of human RASSF7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RASSF7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes with gamma-tubulin|
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Provided below are standard protocols that you may find useful for product applications.
RASSF7 contains 1 Ras-associating domain. It is a centrosome-associated protein required to form a spindle and complete mitosis in the neural tube. There are two isoforms.
Recino, A., et al. Biochem. J. 430(2):207-213(2010)
Lescai, F., et al. Eur. J. Hum. Genet. 17(11):1515-1519(2009)
Sherwood, V., et al. Mol. Biol. Cell 19(4):1772-1782(2008)
Tsang, H.T., et al. Genomics 88(3):333-346(2006)
Iarmolinskii, D.G., et al. Tsitol. Genet. 38(1):9-14(2004)
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