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GUCY2F Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P51841 |
| Other Accession | P51842, Q5SDA5, O02740, NP_001513.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 124850 Da |
| Antigen Region | 828-856 aa |
| Gene ID | 2986 |
|---|---|
| Other Names | Retinal guanylyl cyclase 2, RETGC-2, Guanylate cyclase 2F, retinal, Guanylate cyclase F, GC-F, Rod outer segment membrane guanylate cyclase 2, ROS-GC2, GUCY2F, GUC2F, RETGC2 |
| Target/Specificity | This GUCY2F antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 828-856 amino acids from the C-terminal region of human GUCY2F. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GUCY2F Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GUCY2F |
|---|---|
| Synonyms | GUC2F, RETGC2 |
| Function | Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (PubMed:7777544). Plays an essential role in phototransduction, by mediating cGMP replenishment (By similarity). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity). |
| Cellular Location | Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:O02740}; Single-pass type I membrane protein |
| Tissue Location | Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa.
References
Blackford, A., et al. Cancer Res. 69(8):3681-3688(2009)
Helten, A., et al. J. Neurochem. 103(4):1439-1446(2007)
Wood, L.D., et al. Hum. Mutat. 27(10):1060-1061(2006)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
Laura, R.P., et al. Biochemistry 37(32):11264-11271(1998)
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