|Application ||WB, E|
|Other Accession||P51842, Q5SDA5, O02740, NP_001513.2|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||124850 Da|
|Antigen Region||828-856 aa|
|Other Names||Retinal guanylyl cyclase 2, RETGC-2, Guanylate cyclase 2F, retinal, Guanylate cyclase F, GC-F, Rod outer segment membrane guanylate cyclase 2, ROS-GC2, GUCY2F, GUC2F, RETGC2|
|Target/Specificity||This GUCY2F antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 828-856 amino acids from the C-terminal region of human GUCY2F.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GUCY2F Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa.
Blackford, A., et al. Cancer Res. 69(8):3681-3688(2009)
Helten, A., et al. J. Neurochem. 103(4):1439-1446(2007)
Wood, L.D., et al. Hum. Mutat. 27(10):1060-1061(2006)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
Laura, R.P., et al. Biochemistry 37(32):11264-11271(1998)
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