|Application ||WB, E|
|Calculated MW||51778 Da|
|Antigen Region||266-295 aa|
|Other Names||Coagulation factor IX, Christmas factor, Plasma thromboplastin component, PTC, Coagulation factor IXa light chain, Coagulation factor IXa heavy chain, F9|
|Target/Specificity||This F9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-295 amino acids from the Central region of human F9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||F9 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.|
|Tissue Location||Detected in blood plasma (at protein level) (PubMed:3857619, PubMed:8295821, PubMed:2592373, PubMed:9169594, PubMed:19846852). Synthesized primarily in the liver and secreted in plasma.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Yang, L., et al. J. Biol. Chem. 285(37):28488-28495(2010)
Kao, C.Y., et al. Thromb. Haemost. 104(2):355-365(2010)
Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)
Arellano, A.R., et al. J. Thromb. Haemost. 8(5):1132-1134(2010)
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