KLHDC8B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8IXV7 |
Other Accession | Q5XIA9, Q9D2D9, Q5E9V5, NP_775817.1 |
Reactivity | Human |
Predicted | Bovine, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 37676 Da |
Antigen Region | 245-273 aa |
Gene ID | 200942 |
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Other Names | Kelch domain-containing protein 8B, KLHDC8B |
Target/Specificity | This KLHDC8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-273 amino acids from the C-terminal region of human KLHDC8B. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | KLHDC8B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KLHDC8B {ECO:0000303|PubMed:19706467} |
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Function | Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010). |
Cellular Location | Cytoplasm. Midbody. Note=In mitotic cells, concentrates in the midbody of the cytoplasmic bridge linking daughter cells as they are about to separate during cytokinesis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma.
References
Krem, M.M., et al. Cell Cycle 9(4):670-675(2010)
Salipante, S.J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(35):14920-14925(2009)
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)
Adams, M.D., et al. Nat. Genet. 4(4):373-380(1993)
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