|Application ||WB, E|
|Other Accession||Q5XIA9, Q9D2D9, Q5E9V5, NP_775817.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||37676 Da|
|Antigen Region||245-273 aa|
|Other Names||Kelch domain-containing protein 8B, KLHDC8B|
|Target/Specificity||This KLHDC8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-273 amino acids from the C-terminal region of human KLHDC8B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KLHDC8B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010).|
|Cellular Location||Cytoplasm. Midbody Note=In mitotic cells, concentrates in the midbody of the cytoplasmic bridge linking daughter cells as they are about to separate during cytokinesis.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma.
Krem, M.M., et al. Cell Cycle 9(4):670-675(2010)
Salipante, S.J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(35):14920-14925(2009)
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)
Adams, M.D., et al. Nat. Genet. 4(4):373-380(1993)
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