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SEPP1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | P49908 |
| Other Accession | NP_001078955.1, NP_005401.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43174 Da |
| Antigen Region | 233-262 aa |
| Gene ID | 6414 |
|---|---|
| Other Names | Selenoprotein P, SeP, SEPP1, SELP |
| Target/Specificity | This SEPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 233-262 amino acids from the Central region of human SEPP1. |
| Dilution | WB~~1:2000 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SEPP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SELENOP {ECO:0000303|PubMed:27645994, ECO:0000312|HGNC:HGNC:10751} |
|---|---|
| Function | Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis. |
| Cellular Location | Secreted. Note=Passes from plasma into the glomerular filtrate where it is removed by endocytosis mediated by LRP2 in the proximal tubule epithelium. {ECO:0000250|UniProtKB:P70274} |
| Tissue Location | Made in the liver and heart and secreted into the plasma. It is also found in the kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.
References
Sun, W., et al. Br. J. Nutr. 104(9):1283-1287(2010)
Roman, M., et al. Transl Res 156(4):242-250(2010)
Meplan, C., et al. Carcinogenesis 31(6):1074-1079(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Takemoto, A.S., et al. Ethn Dis 20 (1 SUPPL 1), S1-S925 (2010) :
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