|Application ||WB, E|
|Calculated MW||54417 Da|
|Antigen Region||455-483 aa|
|Other Names||Probable ATP-dependent RNA helicase DDX6, ATP-dependent RNA helicase p54, DEAD box protein 6, Oncogene RCK, DDX6, HLR2, RCK|
|Target/Specificity||This DDX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 455-483 amino acids from the C-terminal region of human DDX6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DDX6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).|
|Cellular Location||Cytoplasm, P-body. Cytoplasm. Nucleus. Note=Upon cellular stress, relocalizes to stress granules (PubMed:26184334)|
|Tissue Location||Abundantly expressed in most tissues.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing.
Naarmann, I.S., et al. RNA 16(11):2189-2204(2010)
Jangra, R.K., et al. J. Virol. 84(13):6810-6824(2010)
Lind, P.A., et al. Twin Res Hum Genet 13(1):10-29(2010)
Han, J.W., et al. Nat. Genet. 41(11):1234-1237(2009)
Minshall, N., et al. Mol. Biol. Cell 20(9):2464-2472(2009)
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