|Application ||WB, E|
|Calculated MW||58027 Da|
|Antigen Region||315-343 aa|
|Other Names||Zinc finger and BTB domain-containing protein 7B, Krueppel-related zinc finger protein cKrox, hcKrox, T-helper-inducing POZ/Krueppel-like factor, Zinc finger and BTB domain-containing protein 15, Zinc finger protein 67 homolog, Zfp-67, Zinc finger protein 857B, Zinc finger protein Th-POK, ZBTB7B, ZBTB15, ZFP67, ZNF857B|
|Target/Specificity||This ZBTB7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 315-343 amino acids from the Central region of human ZBTB7B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZBTB7B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ZBTB15, ZFP67, ZNF857B|
|Function||Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes (e.g., COL1A1; MIM 120150) and has a role in development.
Zhang, M., et al. J. Immunol. 185(7):3960-3969(2010) Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009) Egawa, T. J. Cell. Biochem. 107(6):1037-1045(2009) Tokunaga, T., et al. Autoimmunity 42(8):653-660(2009) Renard, E., et al. J. Cell. Mol. Med. 12 (6B), 2836-2847 (2008) :
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