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CSRP3 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CSRP3 Antibody (Center) AP17004c
    CSRP3 Antibody (Center) (Cat. #AP17004c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CSRP3 antibody detected the CSRP3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P50461
Other Accession NP_001121128.1, NP_003467.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 20969 Da
Antigen Region 91-119 aa
Additional Information
Gene ID 8048
Other Names Cysteine and glycine-rich protein 3, Cardiac LIM protein, Cysteine-rich protein 3, CRP3, LIM domain protein, cardiac, Muscle LIM protein, CSRP3, CLP, MLP
Target/Specificity This CSRP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-119 amino acids from the Central region of human CSRP3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCSRP3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CSRP3
Synonyms CLP, MLP
Function Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity).
Cellular Location Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Mainly cytoplasmic (By similarity). In the nucleus it associates with the actin cytoskeleton (Potential). In the Z line, found associated with GLRX3 (By similarity) {ECO:0000250, ECO:0000305}
Tissue Location Cardiac and slow-twitch skeletal muscles.
Research Areas
Citations (0)

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This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)
Rampersaud, E., et al. Ann. Hum. Genet. 74(2):110-116(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Moller, D.V., et al. Eur. J. Heart Fail. 11(11):1031-1035(2009)

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$ 295.00
$ 99.00
Cat# AP17004c
(40 western blots)
Availability: In Stock
Bulk Size
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