|Application ||WB, E|
|Calculated MW||53372 Da|
|Antigen Region||318-347 aa|
|Other Names||Bone morphogenetic protein 3, BMP-3, Bone morphogenetic protein 3A, BMP-3A, Osteogenin, BMP3, BMP3A|
|Target/Specificity||This BMP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-347 amino acids from the C-terminal region of human BMP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BMP3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.|
|Tissue Location||Expressed in adult and fetal cartilage.|
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Provided below are standard protocols that you may find useful for product applications.
BMP3 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein, also known as osteogenin, induces bone formation.
Stewart, A., et al. J. Cell. Physiol. 223(3):658-666(2010)
Chen, X.R., et al. World J. Gastroenterol. 16(11):1409-1413(2010)
Wu, D.D., et al. PLoS ONE 5 (6), E10959 (2010) :
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
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