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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TP53RK Antibody (C-term)   

TP53RK Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TP53RK Antibody (C-term) AP17010b
    All lanes : Anti-TP53RK Antibody (C-term) at 1:1000 dilution Lane 1: Jurkat whole cell lysate Lane 2: K562 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 28 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - TP53RK Antibody (C-term) AP17010b
    TP53RK Antibody (C-term) (Cat. #AP17010b) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the TP53RK antibody detected the TP53RK protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96S44
Other Accession Q99PW4, NP_291028.3
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 28160 Da
Antigen Region 221-250 aa
Additional Information
Gene ID 112858
Other Names TP53-regulating kinase, Atypical serine/threonine protein kinase TP53RK, EKC/KEOPS complex subunit TP53RK, 36--, Nori-2, p53-related protein kinase, TP53RK, C20orf64, PRPK
Target/Specificity This TP53RK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-250 amino acids from the C-terminal region of human TP53RK.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTP53RK Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TP53RK
Synonyms C20orf64, PRPK
Function Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.
Cellular Location Nucleus.
Tissue Location Highly expressed in testis. Weakly expressed in heart kidney and spleen
Research Areas
Citations (0)

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Protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.


Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Facchin, S., et al. Cell. Mol. Life Sci. 64 (19-20), 2680-2689 (2007) :
Abe, Y., et al. Biochem. Biophys. Res. Commun. 344(1):377-385(2006)
Facchin, S., et al. FEBS Lett. 549 (1-3), 63-66 (2003) :
Miyoshi, A., et al. Biochem. Biophys. Res. Commun. 303(2):399-405(2003)

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$ 295.00
$ 99.00
Cat# AP17010b
(40 western blots)
Availability: In Stock
Bulk Size
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