|Application ||WB, E|
|Other Accession||NP_001672.1, NP_001129237.1|
|Calculated MW||114757 Da|
|Antigen Region||374-403 aa|
|Other Names||Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, SERCA2, SR Ca(2+)-ATPase 2, Calcium pump 2, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, Endoplasmic reticulum class 1/2 Ca(2+) ATPase, ATP2A2, ATP2B|
|Target/Specificity||This ATP2A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-403 amino acids from the Central region of human ATP2A2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATP2A2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Tuusa, J.T., et al. FEBS J. 277(13):2815-2829(2010)
Godic, A., et al. Eur J Dermatol 20(3):271-275(2010)
Godic, A., et al. J. Am. Acad. Dermatol. 62(5):819-823(2010)
Kiec-Wilk, B., et al. Prz. Lek. 67(3):151-156(2010)
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