|Application ||WB, E|
|Calculated MW||37717 Da|
|Antigen Region||177-206 aa|
|Other Names||Antigen-presenting glycoprotein CD1d, R3G1, CD1d, CD1D|
|Target/Specificity||This CD1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-206 amino acids from the Central region of human CD1D.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD1D Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.|
|Cellular Location||Cell membrane; Single- pass type I membrane protein Basolateral cell membrane; Single- pass type I membrane protein Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single- pass type I membrane protein Endoplasmic reticulum membrane; Single-pass type I membrane protein Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.|
|Tissue Location||Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail.
Miura, S., et al. J. Virol. 84(22):11614-11623(2010)
Moll, M., et al. Blood 116(11):1876-1884(2010)
Liu, J., et al. J. Immunol. 184(9):4973-4981(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Brandl, C., et al. PLoS ONE 5 (5), E10800 (2010) :
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