|Application ||WB, E|
|Calculated MW||14326 Da|
|Antigen Region||59-88 aa|
|Other Names||Antileukoproteinase, ALP, BLPI, HUSI-1, Mucus proteinase inhibitor, MPI, Protease inhibitor WAP4, Secretory leukocyte protease inhibitor, Seminal proteinase inhibitor, WAP four-disulfide core domain protein 4, SLPI, WAP4, WFDC4|
|Target/Specificity||This SLPI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-88 amino acids from the Central region of human SLPI.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLPI Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues.|
|Tissue Location||Mucous fluids.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have broad-spectrum anti-biotic activity.
Chotirmall, S.H., et al. Am. J. Respir. Crit. Care Med. 182(1):62-72(2010)
Rasool, N., et al. Clin. Cancer Res. 16(2):600-609(2010)
Ghasemlou, N., et al. Brain 133 (PT 1), 126-138 (2010) :
Taggart, C.C., et al. J. Biol. Chem. 276(36):33345-33352(2001)
Ohlsson, K., et al. J. Androl. 16(1):64-74(1995)
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