|Application ||WB, E|
|Other Accession||NP_003978.2, NP_000269.2|
|Calculated MW||44706 Da|
|Antigen Region||187-216 aa|
|Other Names||Paired box protein Pax-2, PAX2|
|Target/Specificity||This PAX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from the Central region of human PAX2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PAX2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS.|
|Tissue Location||Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system|
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Provided below are standard protocols that you may find useful for product applications.
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.
Monte, N.M., et al. Cancer Res. 70(15):6225-6232(2010)
Ozcan, A., et al. Arch. Pathol. Lab. Med. 134(8):1121-1129(2010)
Quick, C.M., et al. Hum. Pathol. 41(8):1145-1149(2010)
Martinovic-Bouriel, J., et al. Am. J. Med. Genet. A 152A (4), 830-835 (2010) :
Rabban, J.T., et al. Am. J. Surg. Pathol. 34(2):137-146(2010)
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