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RCOR1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UKL0 |
| Other Accession | Q8CFE3, NP_055971.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 53327 Da |
| Antigen Region | 101-130 aa |
| Gene ID | 23186 |
|---|---|
| Other Names | REST corepressor 1, Protein CoREST, RCOR1, KIAA0071, RCOR |
| Target/Specificity | This RCOR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-130 amino acids from the N-terminal region of human RCOR1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RCOR1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RCOR1 |
|---|---|
| Synonyms | KIAA0071, RCOR |
| Function | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:15897453}. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner |
| Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The RCOR gene encodes a functional corepressor required for regulation of neural-specific gene expression.[supplied by OMIM].
References
Xiao, J., et al. J. Orthop. Res. 28(12):1569-1575(2010)
Everett, R.D. J. Virol. 84(7):3695-3698(2010)
Das, C., et al. J. Mol. Biol. 397(1):1-12(2010)
Laurent, B., et al. Stem Cells 27(9):2153-2162(2009)
Wang, Y., et al. Cell 138(4):660-672(2009)
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