HRH4 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q96LD9 |
Other Accession | Q9H3N8 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 44470 Da |
Antigen Region | 359-390 aa |
Other Names | Histamine receptor H4; |
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Target/Specificity | This HRH4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 359-390 amino acids from the C-terminal region of human HRH4. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | HRH4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | H4 {ECO:0000313|EMBL:AAL09297.1} |
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Cellular Location | Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H4 belongs to the family 1 of G protein-coupled receptors and has the highest homology to histamine receptor H3 among known G protein-coupled receptors.
References
Lippert, U., et al., J. Invest. Dermatol. 123(1):116-123 (2004).
Coge, F., et al., Biochem. Biophys. Res. Commun. 284(2):301-309 (2001).
Morse, K.L., et al., J. Pharmacol. Exp. Ther. 296(3):1058-1066 (2001).
Zhu, Y., et al., Mol. Pharmacol. 59(3):434-441 (2001).
Liu, C., et al., Mol. Pharmacol. 59(3):420-426 (2001).
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