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RGS11 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O94810 |
| Other Accession | NP_899180.1, NP_003825.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52946 Da |
| Antigen Region | 205-234 aa |
| Gene ID | 8786 |
|---|---|
| Other Names | Regulator of G-protein signaling 11, RGS11, RGS11 |
| Target/Specificity | This RGS11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the Central region of human RGS11. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RGS11 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RGS11 |
|---|---|
| Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.
References
Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Saleem, Y., et al. Biochem. Biophys. Res. Commun. 386(1):65-70(2009)
Martin, J., et al. Nature 432(7020):988-994(2004)
Sierra, D.A., et al. Genomics 79(2):177-185(2002)
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