|Application ||WB, E|
|Other Accession||NP_899180.1, NP_003825.1|
|Calculated MW||52946 Da|
|Antigen Region||205-234 aa|
|Other Names||Regulator of G-protein signaling 11, RGS11, RGS11|
|Target/Specificity||This RGS11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the Central region of human RGS11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RGS11 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.
Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Saleem, Y., et al. Biochem. Biophys. Res. Commun. 386(1):65-70(2009)
Martin, J., et al. Nature 432(7020):988-994(2004)
Sierra, D.A., et al. Genomics 79(2):177-185(2002)
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