|Application ||WB, E|
|Calculated MW||86161 Da|
|Antigen Region||299-328 aa|
|Other Names||Protein transport protein Sec23A, SEC23-related protein A, SEC23A|
|Target/Specificity||This SEC23A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-328 amino acids from the Central region of human SEC23A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEC23A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.|
|Cellular Location||Smooth endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Note=In the ribosome-free transitional face of the ER and associated vesicles|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Townley, A.K., et al. J. Cell. Sci. 121 (PT 18), 3025-3034 (2008) :
Stagg, S.M., et al. Cell 134(3):474-484(2008)
Bi, X., et al. Dev. Cell 13(5):635-645(2007)
Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007)
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