KIF20A Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O95235 |
Other Accession | P97329, NP_005724.1 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 100278 Da |
Antigen Region | 198-226 aa |
Gene ID | 10112 |
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Other Names | Kinesin-like protein KIF20A, GG10_2, Mitotic kinesin-like protein 2, MKlp2, Rab6-interacting kinesin-like protein, Rabkinesin-6, KIF20A, MKLP2, RAB6KIFL |
Target/Specificity | This KIF20A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-226 amino acids from the N-terminal region of human KIF20A. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | KIF20A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KIF20A |
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Synonyms | MKLP2, RAB6KIFL |
Function | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end- directed motility. |
Cellular Location | Golgi apparatus. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle midzone during anaphase and telophase. |
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Provided below are standard protocols that you may find useful for product applications.
Background
KIF20A interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility (By similarity).
References
Hummer, S., et al. Curr. Biol. 19(7):607-612(2009)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)
Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)
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