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HRH4 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - HRH4 Antibody (Center) AP17035C
    HRH4 Antibody (Center) (Cat. #AP17035c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the HRH4 antibody detected the HRH4 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H3N8
Other Accession NP_067637.2, NP_001153638.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 44496 Da
Antigen Region 228-256 aa
Additional Information
Gene ID 59340
Other Names Histamine H4 receptor, H4R, HH4R, AXOR35, G-protein coupled receptor 105, GPRv53, Pfi-013, SP9144, HRH4, GPCR105
Target/Specificity This HRH4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-256 amino acids from the Central region of human HRH4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHRH4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HRH4
Synonyms GPCR105
Function The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node
Research Areas
Citations (0)

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Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene.


Yu, B., et al. Br. J. Dermatol. 163(5):935-940(2010)
Gschwandtner, M., et al. Allergy 65(7):840-849(2010)
Yu, B., et al. Br. J. Dermatol. 162(5):1038-1043(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Smits, R.A., et al. J. Med. Chem. 53(6):2390-2400(2010)

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$ 295.00
$ 99.00
Cat# AP17035C
(40 western blots)
Availability: In Stock
Bulk Size
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