|Application ||WB, E|
|Other Accession||NP_067637.2, NP_001153638.1|
|Calculated MW||44496 Da|
|Antigen Region||228-256 aa|
|Other Names||Histamine H4 receptor, H4R, HH4R, AXOR35, G-protein coupled receptor 105, GPRv53, Pfi-013, SP9144, HRH4, GPCR105|
|Target/Specificity||This HRH4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-256 amino acids from the Central region of human HRH4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HRH4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node|
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Provided below are standard protocols that you may find useful for product applications.
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene.
Yu, B., et al. Br. J. Dermatol. 163(5):935-940(2010)
Gschwandtner, M., et al. Allergy 65(7):840-849(2010)
Yu, B., et al. Br. J. Dermatol. 162(5):1038-1043(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Smits, R.A., et al. J. Med. Chem. 53(6):2390-2400(2010)
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