|Application ||WB, E|
|Other Accession||NP_001035059.1, NP_008837.1|
|Calculated MW||63538 Da|
|Antigen Region||1-30 aa|
|Other Names||Tyrosine-protein phosphatase non-receptor type 5, Neural-specific protein-tyrosine phosphatase, Striatum-enriched protein-tyrosine phosphatase, STEP, PTPN5|
|Target/Specificity||This PTPN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PTPN5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTPN5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
STEP (Protein-tyrosine phosphatase striatum-enriched) is a neural-specific protein-tyrosine phosphatase. It is also known as PTPN5 (tyrosine-protein phosphatase, non-receptor type 5). STEP immunoreactive areas are most intense in the regions of the CNS receiving a dopaminergic input (e.g. striatum, basal ganglia). STEP is part of the NMDA receptor (R) complex and inhibits NMDAR single-channel activity and NMDAR-mediated synaptic current. Phosphorylation of STEP, via D1 and PKA activation by dopamine, decreases the activity of STEP by reducing its affinity for substrate.
Kurup, P., et al. J. Neurosci. 30(17):5948-5957(2010)
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Korff, S., et al. BMC Cancer 8, 329 (2008) :
Eswaran, J., et al. Biochem. J. 395(3):483-491(2006)
Nguyen, T.H., et al. J. Biol. Chem. 277(27):24274-24279(2002)
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