|Application ||WB, E|
|Calculated MW||133353 Da|
|Antigen Region||695-723 aa|
|Other Names||Myotubularin-related protein 4, FYVE domain-containing dual specificity protein phosphatase 2, FYVE-DSP2, Zinc finger FYVE domain-containing protein 11, MTMR4, KIAA0647, ZFYVE11|
|Target/Specificity||This MTMR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 695-723 amino acids from the Central region of human MTMR4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MTMR4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized to perinuclear region|
|Tissue Location||Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow|
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Provided below are standard protocols that you may find useful for product applications.
Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).
Yu, J., et al. J. Biol. Chem. 285(11):8454-8462(2010) Dolley, G., et al. Mol. Genet. Metab. 97(2):149-154(2009) Plant, P.J., et al. Biochem. J. 419(1):57-63(2009) Colland, F., et al. Genome Res. 14(7):1324-1332(2004) Zhao, R., et al. Exp. Cell Res. 265(2):329-338(2001)
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